Mayo Clinic Research

In an article on Why Good Hospital Ventilation Can't Always Stop Infection, Mayo Clinic biomedical engineering researcher Connie B. Chang, Ph.D., who leads ARPA-H BREATHE's Hospital Air QUality (HAIQU): Breathing Life into Patient Care project, shared that current research uses computational airflow modeling to understand how air moves through spaces and to identify the most effective ways to optimize indoor air quality and create healthier environments for patients and staff. Read more: https://wb.md/4v1ilyu

Mayo Clinic researchers have identified that an immune system molecule, known as ST8Sia6, plays a role in maintaining immune cell balance in the gut — and may help explain why some cases of Crohn’s disease and ulcerative colitis are resistant to standard anti-TNF therapies. Published in Cell Reports, the study found that when ST8Sia6 was absent or reduced in preclinical models, inflammatory immune cells accumulated in the intestines and inflammatory signaling increased dramatically. Notably, inflammation caused by absent or reduced ST8Sia6 did not improve with TNF-alpha treatment, suggesting this may represent an entirely different biological pathway driving disease. The team previously studied ST8Sia6 in connection with cancer and Type 1 diabetes, and this is the first time the molecule has been characterized in gut immune regulation. A mutation in the ST8Sia6 gene appears more frequently in people with Crohn’s disease. With nearly 3 million people in the U.S. affected by IBD, identifying the various mechanisms behind chronic intestinal inflammation is essential for developing new treatment approaches. Congratulations to Virginia Shapiro, Ph.D., first author Sydney Crotts, PhD, and the Mayo Clinic research team on advancing our understanding of immune regulation in IBD. Learn more: https://lnkd.in/gTVP6Yxr #IBD #CrohnsDisease #UlcerativeColitis #Immunology #Gastroenterology #MayoClinic

Today on Clinical Trials Day, we recognize the incredible work of our clinical research community and the progress it makes possible for patients around the world. Discover more: https://lnkd.in/gnduzQG #ClinicalTrialsDay #CTD2026 #ResearchRising

Across Mayo Clinic, more than 1,400 research professionals are advancing studies that bring innovative therapies closer to those who need them most. From researchers and clinicians to coordinators, specialists, nurses and data teams — this work is powered by collaboration. We are especially grateful to the patients whose trust and partnership remain at the heart of every clinical trial. As the landscape of research evolves, so does our approach. This year, we’ve initiated 75+ virtual clinical trials, expanding access to patients in rural communities and bringing research closer to home. At the same time, we continue to reduce trial activation timelines — helping promising therapies reach patients faster. Together, we're accelerating discovery, expanding access and shaping the future of medicine. Discover more: https://lnkd.in/gnduzQG #ClinicalTrialsDay #CTD2026 #ResearchRising

How do we use AI to turn real patient data into evidence clinicians and regulators can trust? Join Yi Qian, Ph.D., vice president of Global Real World Evidence at Johnson & Johnson at Mayo Clinic's AI Research Summit, June 4–5 in Rochester, Minnesota, and online. Dr. Qian will deliver a keynote presentation: "From Promise to Impact: The Intelligent Evolution of Evidence for Confident Clinical and Regulatory Decisions." This discussion will draw on real-world case studies, demonstrating how integrated, multimodal approaches are actively de-risking programs and accelerating regulatory decisions. This session will explore the application of AI-driven disease progression models to enhance trial design, the development of purpose-built AI tools that democratize advanced analytics, and the strategic use of patient digital twins to guide development decisions. She will be joined by a panel with Mayo leaders, including: • Michelle McGowan, Ph.D., senior associate consultant, Department of Artificial Intelligence & Informatics • Demilade Adedinsewo, M.B., Ch.B., consultant, Division of Cardiovascular Medicine • Imon Banerjee, Ph.D., consultant, Department of Artificial Intelligence & Informatics • Barbara Barry, Ph.D., senior associate consultant, Division of Health Care Delivery Research • Amos Lal, M.B.B.S., associate professor of medicine, Department of Pulmonary and Critical Care Medicine Mayo Clinic's AI Research Summit brings together researchers, clinicians, innovators and students to explore new methods and ignite collaboration. This year's focus is on how multi-agent modeling and simulation can help generate clinically meaningful, real-world evidence. Additional keynote speakers include experts from Mayo Clinic, the University of Pennsylvania and Johnson & Johnson. Register by May 30: https://ai-summit.com/ #AIResearchSummit #MayoClinic #AI

Join us in congratulating, Melissa E. Murray, Ph.D., and Dennis Dickson, M.D., on receiving the 2026 The Rainwater Charitable Foundation Prize at #Tau2026.

We hope you will join Vijay Shah, M.D., our Executive Dean of Research at the AI Research Summit next month, to be part of the discussion on how AI is transforming healthcare. Register by May 30: https://ai-summit.com/ #AIResearchSummit #MayoClinic #AI #HealthcareAI

If AI helps generate a discovery, what makes that discovery scientifically sound? Join Cui Tao, PhD FACMI, the Nancy Peretsman and Robert Scully Chair, Department of Artificial Intelligence and Informatics at Mayo Clinic, for the AI Research Summit, June 4–5 in Rochester, Minnesota, and online. Dr. Tao will deliver a keynote talk: "The Scientific Foundations of AI-Enabled Discovery." This keynote will examine the scientific foundations needed to make AI-enabled discovery rigorous, reproducible and translatable, with a focus on methods, infrastructure and interdisciplinary collaboration. The talk will highlight how stronger systems for research design and validation can help move AI from promising innovation to meaningful clinical and scientific impact. Mayo Clinic's AI Research Summit brings together researchers, clinicians, innovators and students to explore new methods and ignite collaboration. This year's focus is on how multi-agent modeling and simulation can help generate clinically meaningful, real-world evidence. Additional keynote speakers include experts from Mayo Clinic, Microsoft, the University of Pennsylvania and Johnson & Johnson. Register by May 30: https://ai-summit.com/ #AIResearchSummit #MayoClinic #AI

How do you use AI research assistants to accelerate cures? Join Matt Redlon, chair of Mayo Clinic's AI Program, at the AI Research Summit, June 4–5 in Rochester, Minnesota, and online. Redlon will deliver a keynote talk: "The Next Wave of Discovery: Agentic AI from Research to Practice." This keynote will explore how emerging AI research assistants are already augmenting scientific workflows, what it will take to scale them effectively, and how they could help drive a step change in the speed of medical discovery. Redlon will pair a practical view of current capabilities with a forward-looking discussion of the people, systems and strategies needed to realize the full potential of AI assistants. Mayo Clinic's AI Research Summit brings together researchers, clinicians, innovators and students to explore new methods and ignite collaboration. This year's focus is on how multi-agent modeling and simulation can help generate clinically meaningful, real-world evidence. Additional keynote speakers include experts from Microsoft, Mayo Clinic, the University of Pennsylvania and Johnson & Johnson. Register by May 30: https://ai-summit.com/ #AIResearchSummit #MayoClinic #AI

Join us in congratulating radiation oncology medical physicist Wei Liu, PhD, DABR, FAAPM, FAIMBE, on being elected as a fellow to the American Institute for Medical and Biological Engineering (AIMBE). Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to medical and biological engineers, comprised of the top 2% of engineers in these fields. "I am deeply honored to be elected as a Fellow of AIMBE. This recognition reflects the collaborative efforts of colleagues and trainees I've had the privilege to work with at Mayo Clinic and beyond. My research has focused on improving the robustness and biological effectiveness of proton therapy, including integrating linear energy transfer into treatment planning, with the goal of delivering safer and more personalized radiation therapy for patients," says Dr. Liu, who is based in Mayo Clinic Arizona. Learn more: https://bit.ly/4wqMitl #AIMBE26