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Tidewave Bio

Tidewave Bio

Biotechnology Research

Los Angeles, CA 339 followers

Point-of-care enabled Precision Medicine for Solid Tumor

About us

Solid tumors remain a significant challenge for even the most advanced therapies, such as CAR-T and checkpoint inhibitors, as these tumors have evolved mechanisms to evade immune responses. Current advanced therapies also face challenges of high costs and lengthy manufacturing timelines, delaying or denying treatment to patients. Tidewave Biotech is addressing these gaps with three key innovations: 1. Enhanced Potency: We engineer immune-modulating cells to elicit a robust anti-cancer immune response. These cells teach and amplify the patient’s natural immune cells to break down solid tumor defenses. 2. Scalable Manufacturing: By leveraging donor-derived hematopoietic stem cells, we achieve economies of scale unattainable by autologous therapies, making treatments more cost-effective. 3. Rapid Personalization: Our point-of-care innovation enables real-time adaptation of our universal cell product to target each patient’s tumor, ensuring immediate and precise treatment. In essence, Tidewave is developing an off-the-shelf universal cell therapy that overcomes solid tumor defenses, reduces costs, and eliminates treatment delays—revolutionizing access to life-saving therapies.

Website
www.tidewavebio.com
Industry
Biotechnology Research
Company size
1 employee
Headquarters
Los Angeles, CA
Type
Privately Held
Founded
2025

Locations

Employees at Tidewave Bio

Updates

  • I read of post recently form Cori Gorman that resonated with me. You can read it here <iframe src="/proxy/https/www.linkedin.com/company/%3Ca%20class="link" href="/proxy/https/lnkd.in/gbp6V96p?trk=organization_guest_main-feed-card_reshare-text" target="_self" rel="nofollow" data-tracking-control-name="organization_guest_main-feed-card_reshare-text" data-tracking-will-navigate>https://lnkd.in/gbp6V96p" height="262" width="504" frameborder="0" allowfullscreen="" title="Embedded post"></iframe> I hope above link works, otherwise you will find it on her feed. One of the biggest reasons advanced therapies (both cell and gene) have progressed more slowly than they should is not just scientific or technical challenges. It is misalignment between the real problem to be solved, the data supporting the program, the development strategy and messaging shared across management, boards, investors, and the public. I have lived versions of this myself. Luckily I was not fired, but I was often ignored or perhaps passed over because I kept raising what seemed to me like basic questions: if an advanced therapy is going to succeed, it needs to deliver transformational value for patients, fit naturally into provider workflow, and have a cost structure that enables broad adoption. The transformational value has always been an important one because of the anticipated cost to patients. Incremental improvement will not cut it. Advanced therapies are not pills that can be manufactured at scale for pennies. Too often, I worked on programs that should have been stopped years earlier, yet the mandate was to “fix” them because I was seen as a problem solver. Communication and alignment are delicate, and not easy to manage. But when they are missing, progress almost always stalls. After 30+ years in cell and gene therapy across multiple modalities and therapeutic areas, I still believe deeply in the field. There have been undeniable breakthroughs, from genetic cures in rare diseases to CAR-T in hematologic cancers. But there is still a lot of work to do to democratize truly transformative therapies and make them practical, scalable, and broadly accessible. That is a big part of why I started Tidewave Bio. My goal now is to build with the full value equation in mind: the unmet need from the patient’s perspective, the realities of the physicians delivering care, and the economic framework that ultimately determines whether innovation reaches people at scale. Ironically, this is not as complicated as we sometimes make it. It starts by asking the right questions, being open to creative solutions, and building a development strategy around a winning value proposition, instead of force-fitting an ill-adapted solution to a made-up problem and then trying to sell it as the flavor of the day. That is what we are trying to do at Tidewave Bio for precision oncology. #AdvancedTherapies #CellTherapy #GeneTherapy #PrecisionOncology #HealthcareInnovation

  • https://lnkd.in/guAT-43z I’m pleased to share that Professor Alexander M.M. Eggermont, MD, PhD has joined Tidewave Bio as Head of our Clinical Advisory Board. Professor Eggermont is widely regarded as one of the leaders who helped shape modern cancer immunotherapy. His career includes serving as Director General of Gustave Roussy, President of EORTC and the European Academy of Cancer Sciences, and senior authorship of landmark immunotherapy trials published in NEJM and The Lancet. His work has directly influenced the evolution of adjuvant immunotherapy and global oncology strategy. As Tidewave advances its biopsy-native, gene-enhanced dendritic cell platform for solid tumors, Alexander’s experience in clinical trial design, translational immunology, and international oncology leadership will be instrumental in refining our development strategy and preparing for IND-enabling activities. Solid tumor immunotherapy continues to face biological and operational barriers. Our goal is to integrate full tumor antigen personalization with scalable immune activation and real-time clinical accessibility. Alexander’s perspective will be critical as we move from platform development toward clinical execution. Looking forward to the work ahead. #Immunotherapy #Oncology #CellTherapy #ClinicalDevelopment #Biotech #SolidTumors #TidewaveBio

  • Great experience collaborating with the JEAP team and deepening our understanding of the Japanese advanced therapy ecosystem and business landscape. Grateful for the insights and connections made throughout the program — and excited to showcase what we’ve built at Demo Day in Tokyo on February 20, 2026 (Fri)! Looking forward to continuing the dialogue with global partners and investors who are passionate about accelerating innovation in advanced therapies and scalable immunotherapy. https://lnkd.in/gEdUNspG #JEAP2025 #AdvancedTherapies #RegenerativeMedicine #TidewaveBio #TokyoDemoDay #Biotech

    View organization page for JETRO - Collaborate &amp; Invest Japan

    31,213 followers

    📣 JEAP: Announcing 10 Global Regenerative Medicine Startups! Demo Day on Feb 20, 2026 (Fri) JETRO's Japan Entry Acceleration Program (JEAP) for regenerative medicine has selected 10 innovative startups from nearly 70 applicants worldwide! As the highlight of the program, we'll host a Demo Day in Tokyo on Feb 20, 2026 (Fri). CDMOs/CROs, investors, Japanese companies, and media—don't miss this opportunity to connect! *Advance registration is required.   ■ Selected Startups: Agnos Therapeutics (USA), website under maintenance Ernexa Therapeutics (USA), https://www.ernexatx.com GenCART (USA), https://lnkd.in/g3jRXYe7 MKC Biotherapeutics (USA), https://lnkd.in/g_DQRRGS Senti Biosciences (USA), https://www.sentibio.com Tidewave Bio (USA), https://lnkd.in/ghfb2Nuv Autolus Therapeutics (UK), https://www.autolus.com/ LIFT BioSciences (UK), https://lnkd.in/gwGSZbxK NextCell Pharma AB (Sweden), https://lnkd.in/e8bY9-u StemSight (Finland), https://www.stemsight.fi/ ■ Demo Day Details: 📅 Feb 20, 2026 (Fri) | 12:00–16:35 📍 Shin Tokyo 4TH, Marunouchi, Tokyo 🎫 Free admission (registration required): https://lnkd.in/gUpXpuME   ----------------------------------------------------------- 📣JEAP:再生医療分野で採択企業10社を発表!2月20日(金)にデモデーを開催! JETROのJapan Entry Acceleration Program (JEAP) 再生医療分野では、このたび約70社にのぼる海外企業の応募の中から、厳選された10社を採択しました! プログラムの成果発表の場として、2026年2月20日(金)に東京でデモデーを開催予定です。 CDMO/CRO・投資家・日本企業・メディアの皆さま、ぜひご来場ください! ※ご来場には、事前申込が必要です。   ■ 採択企業10社: Agnos Therapeutics (USA), ウェブサイトメンテナンス中 Ernexa Therapeutics (USA), https://www.ernexatx.com GenCART (USA), https://lnkd.in/g3jRXYe7 MKC Biotherapeutics (USA), https://lnkd.in/g_DQRRGS Senti Biosciences (USA), https://www.sentibio.com Tidewave Bio (USA), https://lnkd.in/ghfb2Nuv Autolus Therapeutics (UK), https://www.autolus.com/ LIFT BioSciences (UK), https://lnkd.in/gwGSZbxK NextCell Pharma AB (Sweden), https://lnkd.in/e8bY9-u StemSight (Finland), https://www.stemsight.fi/ ■ デモデー詳細: 📅 2026年2月20日(金)12:00~16:35 📍 Shin Tokyo 4TH(東京都千代田区丸の内3丁目3-1 新東京ビル4F) 🎫 参加無料(こちらからお申込みください): https://lnkd.in/gUpXpuME   #JEAP #JEAP2025 #RegenerativeMedicine #CGT #Startup #Collaboration #Innovation

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  • 🌊 On the Concept of Convergence After 30+ years working across biologics, cell therapy, biomaterials, medical devices, and biosurgery, I’ve learned one thing: breakthroughs rarely come from a single field — they come from convergence. At Tidewave Bio, this principle drives everything we do. Our goal is bold — to make advanced cell therapy finally work for the 90% of cancer patients with solid tumors. That means combining potent biology, smart simple device engineering, and procedural innovation to deliver powerful therapies that are scalable, fast, and cost-effective. 👇 Read on to see why the tools to make this possible already exist — and how we’re bringing them together at Tidewave Bio. I’ve been using this term a lot lately — in presentations, on our website, in conversations — because convergence truly sits at the heart of Tidewave Bio’s innovation. At Tidewave Bio, convergence means more than just adding AI or digital tools to the mix. Our mission is to make advanced cell therapy finally work for the broader population of solid tumor patients — those who have been left behind by today’s personalized therapies. To do that, we need both: Potent biology — to overcome the inherent challenges of solid tumors. A reimagined business and delivery model — to make this therapy scalable, rapid, and cost-effective for real-world deployment. That’s why our approach blends cell therapy, device engineering, and procedural innovation. From tumor-tissue processing and real-time release testing to turnkey hospital workflows, every element is designed to collapse the gap between diagnosis and intervention — transforming patient care from complex to accessible. 💡 The exciting part is that the tools to make this possible already exist. The science, the devices, the workflows — they’re all here. The real challenge is to bring them together, align them under a common mission, and deliver. At Tidewave Bio, we’re building that convergence — uniting scientists, engineers, oncologists, surgeons, nurses and integrating technologies across disciplines to make a tangible impact for patients with limited treatment options. For our team, convergence isn’t just a concept — it’s our roadmap. #Convergence #CellTherapy #Immunotherapy #Oncology #BiotechInnovation #MedTech #DigitalHealth #ProceduralInnovation #TranslationalScience #FutureOfMedicine #TidewaveBio

  • https://lnkd.in/gYNgd7tH Even as some players pull back, investment in cell therapy innovation continues to grow — reaffirming both the scale of the opportunity and the life-changing potential these therapies hold for cancer patients. Kite’s recent $1.5B partnership with Pregene is a strong reminder that the field is far from saturated. Cell therapy is still in its early innings — and the next wave of innovation is about accessibility, scalability, and precision. At Tidewave Bio, we’re transforming the business model of cell therapy with a universal, off-the-shelf product that can be instantly personalized at the point of care using a patient’s own tumor biopsy. This innovation combines scalability and real-time personalization — overcoming today’s core limitations in treating solid tumors, including heterogeneity and immune evasion. One universal product, transformed into a patient-specific precision medicine at the point of care. A scalable, potent, and broadly accessible platform is an undeniable value proposition — for patients, clinicians, and investors alike. #CellTherapy #OncologyInnovation #PrecisionMedicine #Immunotherapy #Biotech #TidewaveBio

  • Tidewave Bio reposted this

    Tidewave Bio is proud to be part of #Biofuture2025! Our Chief Medical Officer, Michael Montgomery, MD, will join a panel discussing Next-Generation Innovation in Oncology, exploring how new approaches are reshaping the future of cancer care. Connect with Michael Montgomery, MD to learn more about how we’re changing the way solid tumor cancer is treated. #Biofuture2025 #Oncology #Innovation #CellTherapy #Immunotherapy #Biotech

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  • Tidewave Bio is proud to be part of #Biofuture2025! Our Chief Medical Officer, Michael Montgomery, MD, will join a panel discussing Next-Generation Innovation in Oncology, exploring how new approaches are reshaping the future of cancer care. Connect with Michael Montgomery, MD to learn more about how we’re changing the way solid tumor cancer is treated. #Biofuture2025 #Oncology #Innovation #CellTherapy #Immunotherapy #Biotech

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  • Tidewave Bio reposted this

    At Tidewave Bio, we’re skipping the biomarker diagnostic step. By combining a small patient tumor biopsy with our universal Antigen Presenting Cells at the point of care, we deliver a real-time, scalable, broad-spectrum precision therapy—relevant to any tumor profile.

    𝐓𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐇𝐞𝐚𝐥𝐭𝐡𝐜𝐚𝐫𝐞: 𝐇𝐨𝐰 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐢𝐬 𝐂𝐡𝐚𝐧𝐠𝐢𝐧𝐠 𝐓𝐡𝐞 𝐆𝐚𝐦𝐞 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐔𝐩𝐝𝐚𝐭𝐞𝐝 𝐏𝐃𝐅: https://lnkd.in/eBibvBvP #Precision_medicine, also known as personalized medicine, is an approach to medical care and treatment that takes into account individual variability in genes, environment, and lifestyle for each person. The goal of precision medicine is to tailor medical decisions, interventions, and treatments to the specific characteristics of each patient, rather than adopting a one-size-fits-all approach. Traditional medicine often relies on general guidelines and population-based treatments, which might not be effective for every individual due to differences in genetics, metabolism, and other factors. Precision medicine aims to address this limitation by considering a person's unique genetic makeup, molecular profiles, and other personal information to provide more accurate diagnoses, treatment plans, and disease prevention strategies. 📢 𝐊𝐞𝐲 𝐜𝐨𝐦𝐩𝐨𝐧𝐞𝐧𝐭𝐬 𝐨𝐟 𝐩𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: ✅ Genomics: This involves studying an individual's genetic information, such as DNA sequences, to identify genetic variations that might contribute to diseases or affect how an individual responds to specific treatments. ✅ Molecular Profiling: Precision medicine also involves analyzing various molecules in the body, such as proteins, metabolites, and RNA, to understand disease mechanisms and tailor treatments accordingly. ✅ Data Integration: Precision medicine relies on a comprehensive approach that incorporates various types of data, including clinical, genetic, environmental, and lifestyle information, to create a more holistic picture of an individual's health. ✅ Targeted Therapies: With the insights gained from genetic and molecular profiling, healthcare providers can develop targeted therapies that address the specific genetic mutations or molecular pathways driving a patient's disease. This approach often leads to more effective and less harmful treatments. ✅ Disease Prevention: Precision medicine not only focuses on treatment but also on disease prevention. By identifying individuals at higher risk of certain conditions, interventions can be designed to prevent the onset of diseases or catch them at an early, more treatable stage. ✅ Data and Technology: Precision medicine heavily relies on advanced technologies, including high-throughput sequencing, bioinformatics, and data analysis tools, to process and interpret vast amounts of patient data.

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