Arrowhead Pharmaceuticals

HoFH doesn't develop over time - you're born with it. And the way it's inherited matters. In most cases, the root cause is thought to involve a mutation in the LDLR gene - which codes for the LDL receptor responsible for clearing cholesterol from the blood. When both copies (inherited from both parents) are impaired, LDL may accumulate largely unchecked. #HoFH101 #HoFHAwarenessDay #Genetics #RareDisease #FamilialHypercholesterolemia

Once again, our CEO Chris Anzalone, PhD was recognized in the LA500 as one of the most influential business leaders in Los Angeles. Congratulations, Chris and thank you to Los Angeles Business Journal. https://lnkd.in/gNTTZpk3

We couldn't be prouder of our incredible team members, who are the foundations of our success. Their dedication to advancing RNAi innovations to improve patients' lives is what makes us who we are. #WeAreArrowhead Thanks to Forbes for the recognition.

Living with a serious rare disease like FCS can feel like a dangerous balancing act, which can take a toll on one's mental health. This May - Mental Health Awareness Month — we want to highlight the importance of community. The emotional support of family and friends, and especially others who truly understand life with FCS, can make a real difference as you navigate the day-to-day uncertainty that comes with it. Find resources and advice from real people living with FCS here: https://lnkd.in/gP66eDVm Managing very high triglycerides can be an emotional challenge as well as a physical one, but you're not alone. #MentalHealth #RareDisease #LivingwithFCS

HoFH is estimated to affect roughly 1 in 300,000 people worldwide. It's rare — but its impact can be profound. Homozygous Familial Hypercholesterolemia — or HoFH — is an ultra-rare genetic condition that causes dangerously elevated LDL cholesterol from birth. Not slightly elevated. LDL levels in children with HoFH can exceed 400 mg/dL, or more than four times what's considered safe — and in some cases may reach as high as 1,000mg/dL. Left unmanaged, this can contribute to serious cardiovascular complications. This May, we're sharing what everyone should know about HoFH. Follow along. 👇 #HoFH101 #HoFHAwarenessDay #FamilialHypercholesterolemia #RareDisease #CardiovascularHealth

Understanding patient lived experiences may help inform more holistic treatment conversations and support strategies. In our latest video series, Julie shares how community support has helped her navigate the emotional and social challenges of living with Familial Chylomicronemia Syndrome (FCS) - a rare genetic disorder that leads to potentially life-threatening episodes of acute pancreatitis. Explore more insights and learn from lived experiences at: www.TalkingFCS.com #FCSAwareness #ForFCS #RareDisease

It's #NationalLipidDay — an opportunity to go beyond "good" and "bad" cholesterol and look at the broader science of lipid health. Lipids serve as the building blocks of cell membranes and a major energy source for muscles and organs. But in rare genetic disorders like Familial Chylomicronemia Syndrome (FCS) and Homozygous Familial Hypercholesterolemia (HoFH), lipids can build up to dangerously high levels — and conventional lipid-lowering treatments are often insufficient. That's why developing new therapeutic approaches for these patients remains so important. Learn more: https://lnkd.in/et8EjSsd

We are hosting a conference call and webcast today at 4:30 p.m. ET to discuss fiscal 2026 second quarter financial results and provide a corporate update. To learn more or participate in the conference call: https://bit.ly/4tG6zZD #Biotech #RNAi #WeAreArrowhead

At Arrowhead, we're ready for what comes next - because we're creating it. Read the story from BioCentury Inc. behind our momentum as we push the frontiers of siRNA innovation: https://lnkd.in/eZmgSyvJ

Lipidologists play a critical role in the care pathway for people living with Familial Chylomicronemia Syndrome (FCS) and Homozygous Familial Hypercholesterolemia (HoFH). With expertise in disorders of lipid metabolism, they can support diagnostic confirmation, coordinate genetic testing and help guide patients toward appropriate disease management strategies, including access to specialized therapies. For clinicians seeking to connect patients with additional expertise, the Foundation of the National Lipid Association offers a searchable directory of lipid specialists: https://lnkd.in/eezcYq9d. #FCSAwareness #ForFCS #RareDisease #Lipidology