diff --git a/CHANGELOG.md b/CHANGELOG.md
index 7e0a518a..27f79c27 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,12 @@
 # Changelog
 
+### [2.2.1](https://www.github.com/googleapis/java-containeranalysis/compare/v2.2.0...v2.2.1) (2021-11-03)
+
+
+### Dependencies
+
+* update dependency io.grafeas:grafeas to v2.1.0 ([#745](https://www.github.com/googleapis/java-containeranalysis/issues/745)) ([cd417dd](https://www.github.com/googleapis/java-containeranalysis/commit/cd417ddb547787c7cf0341684b96816d2da7ffd7))
+
 ## [2.2.0](https://www.github.com/googleapis/java-containeranalysis/compare/v2.1.9...v2.2.0) (2021-10-27)
 
 
diff --git a/google-cloud-containeranalysis-bom/pom.xml b/google-cloud-containeranalysis-bom/pom.xml
index a11523a9..0b52795d 100644
--- a/google-cloud-containeranalysis-bom/pom.xml
+++ b/google-cloud-containeranalysis-bom/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-containeranalysis-bom</artifactId>
-  <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+  <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   <packaging>pom</packaging>
   <parent>
     <groupId>com.google.cloud</groupId>
@@ -53,27 +53,27 @@
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-containeranalysis-v1</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
+        <version>2.2.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-containeranalysis-v1beta1</artifactId>
-        <version>0.92.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
+        <version>0.92.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-containeranalysis</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+        <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-containeranalysis-v1</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
+        <version>2.2.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-containeranalysis-v1beta1</artifactId>
-        <version>0.92.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
+        <version>0.92.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
       </dependency>
     </dependencies>
   </dependencyManagement>
diff --git a/google-cloud-containeranalysis/pom.xml b/google-cloud-containeranalysis/pom.xml
index 38098c16..428d4612 100644
--- a/google-cloud-containeranalysis/pom.xml
+++ b/google-cloud-containeranalysis/pom.xml
@@ -3,7 +3,7 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-containeranalysis</artifactId>
-  <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+  <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   <packaging>jar</packaging>
   <name>Google Cloud Container Analysis</name>
   <url>https://github.com/googleapis/java-containeranalysis</url>
@@ -11,7 +11,7 @@
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-containeranalysis-parent</artifactId>
-    <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+    <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   </parent>
   <properties>
     <site.installationModule>google-cloud-containeranalysis</site.installationModule>
diff --git a/grpc-google-cloud-containeranalysis-v1/pom.xml b/grpc-google-cloud-containeranalysis-v1/pom.xml
index fa0e8e77..ce257967 100644
--- a/grpc-google-cloud-containeranalysis-v1/pom.xml
+++ b/grpc-google-cloud-containeranalysis-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-cloud-containeranalysis-v1</artifactId>
-  <version>2.2.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
+  <version>2.2.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
   <name>grpc-google-cloud-containeranalysis-v1</name>
   <description>GRPC library for grpc-google-cloud-containeranalysis-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-containeranalysis-parent</artifactId>
-    <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+    <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/grpc-google-cloud-containeranalysis-v1beta1/pom.xml b/grpc-google-cloud-containeranalysis-v1beta1/pom.xml
index f8445aaa..f25f8c30 100644
--- a/grpc-google-cloud-containeranalysis-v1beta1/pom.xml
+++ b/grpc-google-cloud-containeranalysis-v1beta1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>grpc-google-cloud-containeranalysis-v1beta1</artifactId>
-  <version>0.92.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
+  <version>0.92.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
   <name>grpc-google-cloud-containeranalysis-v1beta1</name>
   <description>GRPC library for grpc-google-cloud-containeranalysis-v1beta1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-containeranalysis-parent</artifactId>
-    <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+    <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/pom.xml b/pom.xml
index 88d28985..2814ce3d 100644
--- a/pom.xml
+++ b/pom.xml
@@ -4,7 +4,7 @@
   <groupId>com.google.cloud</groupId>
   <artifactId>google-cloud-containeranalysis-parent</artifactId>
   <packaging>pom</packaging>
-  <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+  <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   <name>Google Cloud Container Analysis Parent</name>
   <url>https://github.com/googleapis/java-containeranalysis</url>
   <description>
@@ -61,27 +61,27 @@
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-containeranalysis-v1</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
+        <version>2.2.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>proto-google-cloud-containeranalysis-v1beta1</artifactId>
-        <version>0.92.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
+        <version>0.92.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-containeranalysis-v1beta1</artifactId>
-        <version>0.92.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
+        <version>0.92.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1beta1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.api.grpc</groupId>
         <artifactId>grpc-google-cloud-containeranalysis-v1</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
+        <version>2.2.1</version><!-- {x-version-update:grpc-google-cloud-containeranalysis-v1:current} -->
       </dependency>
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>google-cloud-containeranalysis</artifactId>
-        <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+        <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
       </dependency>
 
       <dependency>
@@ -96,7 +96,7 @@
       <dependency>
         <groupId>io.grafeas</groupId>
         <artifactId>grafeas</artifactId>
-        <version>2.0.6</version>
+        <version>2.1.0</version>
       </dependency>
       <!-- TODO: Until gax-grpc && grafeas align  -->
 
diff --git a/proto-google-cloud-containeranalysis-v1/pom.xml b/proto-google-cloud-containeranalysis-v1/pom.xml
index 7d97fb35..cf29a97b 100644
--- a/proto-google-cloud-containeranalysis-v1/pom.xml
+++ b/proto-google-cloud-containeranalysis-v1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-cloud-containeranalysis-v1</artifactId>
-  <version>2.2.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
+  <version>2.2.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1:current} -->
   <name>proto-google-cloud-containeranalysis-v1</name>
   <description>PROTO library for proto-google-cloud-containeranalysis-v1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-containeranalysis-parent</artifactId>
-    <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+    <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/GetVulnerabilityOccurrencesSummaryRequest.java b/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/GetVulnerabilityOccurrencesSummaryRequest.java
index 7231b6fc..66322147 100644
--- a/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/GetVulnerabilityOccurrencesSummaryRequest.java
+++ b/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/GetVulnerabilityOccurrencesSummaryRequest.java
@@ -241,10 +241,10 @@ public final boolean isInitialized() {
 
   @java.lang.Override
   public void writeTo(com.google.protobuf.CodedOutputStream output) throws java.io.IOException {
-    if (!getParentBytes().isEmpty()) {
+    if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(parent_)) {
       com.google.protobuf.GeneratedMessageV3.writeString(output, 1, parent_);
     }
-    if (!getFilterBytes().isEmpty()) {
+    if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(filter_)) {
       com.google.protobuf.GeneratedMessageV3.writeString(output, 2, filter_);
     }
     unknownFields.writeTo(output);
@@ -256,10 +256,10 @@ public int getSerializedSize() {
     if (size != -1) return size;
 
     size = 0;
-    if (!getParentBytes().isEmpty()) {
+    if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(parent_)) {
       size += com.google.protobuf.GeneratedMessageV3.computeStringSize(1, parent_);
     }
-    if (!getFilterBytes().isEmpty()) {
+    if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(filter_)) {
       size += com.google.protobuf.GeneratedMessageV3.computeStringSize(2, filter_);
     }
     size += unknownFields.getSerializedSize();
diff --git a/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/VulnerabilityOccurrencesSummary.java b/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/VulnerabilityOccurrencesSummary.java
index b1835121..79eaabc8 100644
--- a/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/VulnerabilityOccurrencesSummary.java
+++ b/proto-google-cloud-containeranalysis-v1/src/main/java/com/google/containeranalysis/v1/VulnerabilityOccurrencesSummary.java
@@ -459,7 +459,7 @@ public final boolean isInitialized() {
 
     @java.lang.Override
     public void writeTo(com.google.protobuf.CodedOutputStream output) throws java.io.IOException {
-      if (!getResourceUriBytes().isEmpty()) {
+      if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(resourceUri_)) {
         com.google.protobuf.GeneratedMessageV3.writeString(output, 1, resourceUri_);
       }
       if (severity_ != io.grafeas.v1.Severity.SEVERITY_UNSPECIFIED.getNumber()) {
@@ -480,7 +480,7 @@ public int getSerializedSize() {
       if (size != -1) return size;
 
       size = 0;
-      if (!getResourceUriBytes().isEmpty()) {
+      if (!com.google.protobuf.GeneratedMessageV3.isStringEmpty(resourceUri_)) {
         size += com.google.protobuf.GeneratedMessageV3.computeStringSize(1, resourceUri_);
       }
       if (severity_ != io.grafeas.v1.Severity.SEVERITY_UNSPECIFIED.getNumber()) {
diff --git a/proto-google-cloud-containeranalysis-v1beta1/pom.xml b/proto-google-cloud-containeranalysis-v1beta1/pom.xml
index 1f7938ab..47849aee 100644
--- a/proto-google-cloud-containeranalysis-v1beta1/pom.xml
+++ b/proto-google-cloud-containeranalysis-v1beta1/pom.xml
@@ -4,13 +4,13 @@
   <modelVersion>4.0.0</modelVersion>
   <groupId>com.google.api.grpc</groupId>
   <artifactId>proto-google-cloud-containeranalysis-v1beta1</artifactId>
-  <version>0.92.0</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
+  <version>0.92.1</version><!-- {x-version-update:proto-google-cloud-containeranalysis-v1beta1:current} -->
   <name>proto-google-cloud-containeranalysis-v1beta1</name>
   <description>PROTO library for proto-google-cloud-containeranalysis-v1beta1</description>
   <parent>
     <groupId>com.google.cloud</groupId>
     <artifactId>google-cloud-containeranalysis-parent</artifactId>
-    <version>2.2.0</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
+    <version>2.2.1</version><!-- {x-version-update:google-cloud-containeranalysis:current} -->
   </parent>
   <dependencies>
     <dependency>
diff --git a/samples/install-without-bom/pom.xml b/samples/install-without-bom/pom.xml
index dc1c6129..16630201 100644
--- a/samples/install-without-bom/pom.xml
+++ b/samples/install-without-bom/pom.xml
@@ -29,7 +29,7 @@
     <dependency>
       <groupId>com.google.cloud</groupId>
       <artifactId>google-cloud-containeranalysis</artifactId>
-      <version>2.1.9</version>
+      <version>2.2.0</version>
     </dependency>
     <!-- [END containeranalysis_install_without_bom] -->
 
diff --git a/samples/snapshot/pom.xml b/samples/snapshot/pom.xml
index 5606724a..3163e8ef 100644
--- a/samples/snapshot/pom.xml
+++ b/samples/snapshot/pom.xml
@@ -28,7 +28,7 @@
     <dependency>
       <groupId>com.google.cloud</groupId>
       <artifactId>google-cloud-containeranalysis</artifactId>
-      <version>2.1.9</version>
+      <version>2.2.0</version>
     </dependency>
 
     <dependency>
diff --git a/samples/snippets/pom.xml b/samples/snippets/pom.xml
index a74c2b59..43653d2f 100644
--- a/samples/snippets/pom.xml
+++ b/samples/snippets/pom.xml
@@ -30,7 +30,7 @@
       <dependency>
         <groupId>com.google.cloud</groupId>
         <artifactId>libraries-bom</artifactId>
-        <version>23.1.0</version>
+        <version>24.0.0</version>
         <type>pom</type>
         <scope>import</scope>
       </dependency>
diff --git a/synth.metadata b/synth.metadata
index 77fce3cd..6d2de4a6 100644
--- a/synth.metadata
+++ b/synth.metadata
@@ -4,15 +4,15 @@
       "git": {
         "name": ".",
         "remote": "https://github.com/googleapis/java-containeranalysis.git",
-        "sha": "ed0df7d8cf7850854844826362d401e87d3870db"
+        "sha": "345cd80877bce3c41d30809461d176d25310b5cf"
       }
     },
     {
       "git": {
         "name": "googleapis",
         "remote": "https://github.com/googleapis/googleapis.git",
-        "sha": "e1738ee972b49fd0c4d4718b035444495142b781",
-        "internalRef": "391407209"
+        "sha": "d2977af9e9f1fc0c9dc8368352daa032471f3c63",
+        "internalRef": "403132955"
       }
     },
     {
diff --git a/versions.txt b/versions.txt
index e13bec78..92e18da9 100644
--- a/versions.txt
+++ b/versions.txt
@@ -1,8 +1,8 @@
 # Format:
 # module:released-version:current-version
 
-proto-google-cloud-containeranalysis-v1:2.2.0:2.2.0
-proto-google-cloud-containeranalysis-v1beta1:0.92.0:0.92.0
-grpc-google-cloud-containeranalysis-v1beta1:0.92.0:0.92.0
-grpc-google-cloud-containeranalysis-v1:2.2.0:2.2.0
-google-cloud-containeranalysis:2.2.0:2.2.0
+proto-google-cloud-containeranalysis-v1:2.2.1:2.2.1
+proto-google-cloud-containeranalysis-v1beta1:0.92.1:0.92.1
+grpc-google-cloud-containeranalysis-v1beta1:0.92.1:0.92.1
+grpc-google-cloud-containeranalysis-v1:2.2.1:2.2.1
+google-cloud-containeranalysis:2.2.1:2.2.1